Isolated Goat Ileum Preparation – an Alternative to Isolated Ileum Preparation for the Three Point Bioassay of Acetylcholine
نویسندگان
چکیده
The objective of the study was to evaluate the use of goat ileum preparation for the estimation of unknown concentration of acetylcholine by three point bioassay. The graded doses of acetylcholine have shown dose dependent increase in contraction of isolated goat ileum. The responses obtained by this tissue preparation were similar to those with guinea pig ileum preparation. The goat ileum can be used successfully in routine pharmacology experiments in place of guinea pig ileum preparation for the three point bioassay of acetylcholine.
منابع مشابه
Isolated goat ileum preparation: An alternative to isolated ileum preparation from laboratory animals
Isolated tissue preparations are commonly used to study the effects of drugs on specific type of receptors. These preparations are also used for bioassay of drugs, characterisation of specific receptor or its subtypes, to determine concentration response curve of an agonist, to study antagonism of drug and in new drug discovery.[1] Isolated heart and rectus abdominis of frog are the two commonl...
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